High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications

Keyphrases

• Antibiotics 100%
• Carbapenems 100%
• Outer Membrane 100%
• Membrane Modification 100%
• PhoPQ 100%
• Meropenem 83%
• Lipopolysaccharide 83%
• Lipids 33%
• Structural Integrity 33%
• Enterobacterales 33%
• Molecular Mechanism 16%
• Colistin 16%
• Polysaccharide 16%
• Amino 16%
• Cell Wall 16%
• Antimicrobial Peptides 16%
• Lactams 16%
• Cell Surface 16%
• Phospholipids 16%
• Clinical Treatment 16%
• Intolerance 16%
• FDA-approved Drugs 16%
• Antibiotic Tolerance 16%
• Electrostatic Interaction 16%
• Membrane Anchor 16%
• Lysis 16%
• Tolerant Cells 16%
• Membrane Structure 16%
• Multidrug-resistant Bacteria 16%
• β-lactam Antibiotics 16%
• Inner Leaflet 16%
• Two-component System 16%
• Enhanced Tolerance 16%
• Antibiotic Failure 16%
• Turgor Pressure 16%
• Asymmetric Bilayer 16%
• Histidine Kinase Inhibitor 16%
• Last-resort Antibiotics 16%
• Maintenance Structure 16%
• MgrB 16%
• Overactivation 16%
• Spheroplast 16%
• Potential Contributor 16%
• Integrity Maintenance 16%
• Aminoarabinose 16%
• Cell Wall-deficiency 16%

Immunology and Microbiology

• Outer Membrane 100%
• Cell Wall 66%
• Enterobacterales 66%
• Cell Surface 33%
• Histidine Kinase 33%
• Static Electricity 33%
• Membrane Structure 33%
• Colistin 33%
• Spheroplast 33%
• Turgor Pressure 33%
• Antimicrobial Peptides 33%
• Lipid Bilayer 33%