TY - JOUR
T1 - High-Dose Vitamin E Does Not Decrease the Rate of Chronic Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency
AU - Johnson, Gerhard J
AU - Vatassery, Govind T.
AU - Finkel, Barbara
AU - Allen, David W
PY - 1983/4/28
Y1 - 1983/4/28
N2 - Several observations made during in vitro and in vivo studies of animal and human erythrocytes have indicated that vitamin E may protect erythrocytes from oxidant-induced damage.1 Previous reports from our laboratory have presented evidence indicating that chronic hemolysis secondary to glucose-6-phosphate dehydrogenase deficiency is attributable to oxidant-induced erythrocyte-membrane injury.2 3 4 Since vitamin E may function as an antioxidant in erythrocytes, its use in patients with glucose-6-phosphate dehydrogenase deficiency accompanied by chronic hemolytic disease has been investigated.1,5,6 Two of these studies indicated that high-dose vitamin E reduced the rate of hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency,1,5 whereas no change was observed.
AB - Several observations made during in vitro and in vivo studies of animal and human erythrocytes have indicated that vitamin E may protect erythrocytes from oxidant-induced damage.1 Previous reports from our laboratory have presented evidence indicating that chronic hemolysis secondary to glucose-6-phosphate dehydrogenase deficiency is attributable to oxidant-induced erythrocyte-membrane injury.2 3 4 Since vitamin E may function as an antioxidant in erythrocytes, its use in patients with glucose-6-phosphate dehydrogenase deficiency accompanied by chronic hemolytic disease has been investigated.1,5,6 Two of these studies indicated that high-dose vitamin E reduced the rate of hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency,1,5 whereas no change was observed.
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U2 - 10.1056/NEJM198304283081708
DO - 10.1056/NEJM198304283081708
M3 - Article
C2 - 6835308
AN - SCOPUS:0020576949
SN - 0028-4793
VL - 308
SP - 1014
EP - 1017
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -