High dose-rate intra-operative radiation therapy during high risk genitourinary surgery: Initial observations and a proposal for its study in bladder cancer

Max Kates, Meera R. Chappidi, Aaron Brant, Niv Milbar, Nikolai A. Sopko, Christian Meyer, Stephanie A. Terezakis, Joseph M. Herman, Jonathan E. Efron, Bashar Safar, Phuoc T. Tran, Nita Ahuja, Phillip M. Pierorazio, Trinity J. Bivalacqua

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: High dose-rate Intra-Operative Radiation Therapy (HD-IORT) is used to provide effective local control for patients with high-risk locally advanced or recurrent tumors. However, the utility of HD-IORT for patients with bladder cancer has not been studied. Objective: To characterize our institutional experience with HD-IORT in patients with cancer requiring genitourinary surgery, in an effort to identify patients with bladder cancer that may benefit from HD-IORT. Methods: We performed a retrospective review of all patients who have undergone HD-IORT during genitourinary surgery at our institution. Patients were stratified by surgical margin status, and primary outcomes assessed were overall survival, recurrence free survival and 90-day complications. Patients undergoing cystectomy and HD-IORT with sarcomatoid urothelial cancer were compared to a similar cohort undergoing cystectomy alone. A sample case of one such patient is discussed in detail. Results: 84 patients at our institution have undergone HD-IORT with genitourinary surgery. Positive surgical margin status was the greatest predictor of both OS (HR=3.42) and RFS (HR=2.61). The overall 90-day complication rate was 61, with wound infections (43) and GI complications (21) being most common. 4 of these patients had sarcomatoid urothelial histology, and all are still alive with >2yrs follow up. This compares to a 52 1 yr survival in our sarcomatoid urothelial cohort (25 pts) that did not undergo HD-IORT. Conclusions: Our institutional experience with HD-IORT has been promising, particularly among patients with locally advanced disease and sarcomatoid histology. We are currently enrolling patients in a multi-institutional registry to assess the utility of HD-IORT in high risk bladder cancer.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalBladder Cancer
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Bladder cancer
  • radiation therapy

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