High-dose chemotherapy and autologous stem-cell transplantation in Korean patients with relapsed or refractory Hodgkin lymphoma

Kwonoh Park, Dok Hyun Yoon, Shin Kim, Chan Sik Park, Jooryung Huh, Sang Wook Lee, Cheolwon Suh

Research output: Contribution to journalArticlepeer-review

Abstract

High-dose chemotherapy and autologous stemcell transplantation (HDCT-ASCT) is a standard therapy for patients with relapsed or refractory Hodgkin lymphoma (HL). However, its efficacy in Asian patients has not been well investigated. A retrospective analysis of outcomes in 10 consecutive patients who underwent ASCT for HL in a single Korean centre from August 2005 to September 2010 was conducted. The median age was 34.5 years (range 17-64 years) and seven patients were male. Six patients were of stage III-IV at presentation. B symptoms were present in six patients. International Prognostic Score (IPS) was as follows: IPS = 1 (n = 5), IPS = 2 (n = 1), IPS = 4 (n = 2), and IPS = 5 (n = 2). The analysis included nine patients with relapsed HL and one primary refractory case. Four patients were in second complete response and the others were in partial response after salvage chemotherapy. With a median follow-up duration of 58.0 months, 3-year progression-free survival rate and overall survival rate from ASCT were 40 and 76 %, respectively. The results suggest that the efficacy of highdose chemotherapy followed by ASCT in Korean patients with refractory or relapsed HL is comparable to that in Western patients.

Original languageEnglish (US)
Pages (from-to)256-262
Number of pages7
JournalInternational Journal of Hematology
Volume97
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Autologous stem-cell transplantation
  • High-dose chemotherapy
  • Hodgkin lymphoma
  • Korea

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