High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards

Jaime Slaughter, Changshuai Wei, Steven J. Korzeniewski, Qing Lu, John S. Beck, Sok Kean Khoo, Ariel Brovont, Joel Maurer, Denny Martin, Madeleine Lenski, Nigel Paneth

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB). Method: Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs. Results: The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets. Conclusion: The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.

Original languageEnglish (US)
Pages (from-to)1765-1767
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume26
Issue number18
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Archived newborn blood spots
  • Genes and transcripts
  • Genome-wide
  • Messenger RNAs
  • Oligonucleotide microarrays

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    Slaughter, J., Wei, C., Korzeniewski, S. J., Lu, Q., Beck, J. S., Khoo, S. K., Brovont, A., Maurer, J., Martin, D., Lenski, M., & Paneth, N. (2013). High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards. Journal of Maternal-Fetal and Neonatal Medicine, 26(18), 1765-1767. https://doi.org/10.3109/14767058.2013.804050