High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards

Jaime Slaughter; Changshuai Wei; Steven J. Korzeniewski; Qing Lu; John S. Beck; Sok Kean Khoo; Ariel Brovont; Joel Maurer; Denny Martin; Madeleine Lenski; Nigel Paneth

doi:10.3109/14767058.2013.804050

High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards

Jaime Slaughter, Changshuai Wei, Steven J. Korzeniewski, Qing Lu, John S. Beck, Sok Kean Khoo, Ariel Brovont, Joel Maurer, Denny Martin, Madeleine Lenski, Nigel Paneth

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB). Method: Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs. Results: The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets. Conclusion: The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.

Original language	English (US)
Pages (from-to)	1765-1767
Number of pages	3
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	26
Issue number	18
DOIs	https://doi.org/10.3109/14767058.2013.804050
State	Published - Dec 2013
Externally published	Yes

Bibliographical note

Funding Information:
The authors have no conflicts of interests. This research was supported in part by the Wayne State University Perinatal Initiative and funded by NIH R01 NS055101 to Dr. Paneth. Dr. Slaughter is funded by T32 HD046377.

Keywords

Archived newborn blood spots
Genes and transcripts
Genome-wide
Messenger RNAs
Oligonucleotide microarrays

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10.3109/14767058.2013.804050

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Slaughter, J., Wei, C., Korzeniewski, S. J., Lu, Q., Beck, J. S., Khoo, S. K., Brovont, A., Maurer, J., Martin, D., Lenski, M., & Paneth, N. (2013). High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards. Journal of Maternal-Fetal and Neonatal Medicine, 26(18), 1765-1767. https://doi.org/10.3109/14767058.2013.804050

Slaughter, J, Wei, C, Korzeniewski, SJ, Lu, Q, Beck, JS, Khoo, SK, Brovont, A, Maurer, J, Martin, D, Lenski, M & Paneth, N 2013, 'High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards', Journal of Maternal-Fetal and Neonatal Medicine, vol. 26, no. 18, pp. 1765-1767. https://doi.org/10.3109/14767058.2013.804050

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abstract = "Objective: To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB). Method: Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs. Results: The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets. Conclusion: The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.",

keywords = "Archived newborn blood spots, Genes and transcripts, Genome-wide, Messenger RNAs, Oligonucleotide microarrays",

author = "Jaime Slaughter and Changshuai Wei and Korzeniewski, {Steven J.} and Qing Lu and Beck, {John S.} and Khoo, {Sok Kean} and Ariel Brovont and Joel Maurer and Denny Martin and Madeleine Lenski and Nigel Paneth",

note = "Funding Information: The authors have no conflicts of interests. This research was supported in part by the Wayne State University Perinatal Initiative and funded by NIH R01 NS055101 to Dr. Paneth. Dr. Slaughter is funded by T32 HD046377.",

year = "2013",

month = dec,

doi = "10.3109/14767058.2013.804050",

language = "English (US)",

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T1 - High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards

AU - Slaughter, Jaime

AU - Wei, Changshuai

AU - Korzeniewski, Steven J.

AU - Lu, Qing

AU - Beck, John S.

AU - Khoo, Sok Kean

AU - Brovont, Ariel

AU - Maurer, Joel

AU - Martin, Denny

AU - Lenski, Madeleine

AU - Paneth, Nigel

N1 - Funding Information: The authors have no conflicts of interests. This research was supported in part by the Wayne State University Perinatal Initiative and funded by NIH R01 NS055101 to Dr. Paneth. Dr. Slaughter is funded by T32 HD046377.

PY - 2013/12

Y1 - 2013/12

N2 - Objective: To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB). Method: Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs. Results: The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets. Conclusion: The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.

AB - Objective: To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB). Method: Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs. Results: The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets. Conclusion: The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.

KW - Archived newborn blood spots

KW - Genes and transcripts

KW - Genome-wide

KW - Messenger RNAs

KW - Oligonucleotide microarrays

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High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards

Abstract

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