High-bandwidth radio frequency Coulter counter

D. K. Wood, S. H. Oh, S. H. Lee, H. T. Soh, A. N. Cleland

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


We demonstrate a method for high-bandwidth, high-sensitivity particle sensing and cell counting in a microfluidic system. Our approach employs a tuned radiofrequency probe, which forms the radiofrequency analog of a Coulter counter. By measuring the reflected rf power, this approach provides an unprecedented detection rate, with a theoretical bandwidth in excess of 10 MHz. Particle detection was performed in a continuous flow mode in a microfluidic channel, using 15 μm diameter polystyrene beads suspended in a sucrose-saline solution. We demonstrate 30 kHz counting rates and show high-resolution bead time-of-flight data, comprising the fastest electronic particle detection on-chip to date.

Original languageEnglish (US)
Article number184106
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number18
StatePublished - Oct 31 2005

Bibliographical note

Funding Information:
This work was supported in part by the Army Research Office through the UCSB Institute for Collaborative Bio-technologies under Contract No. DAAD19-03-D-0004, the DMEA/DARPA Center for Nanoscience Innovation for Defense, and the ONR Young Investigator Program N000140410456.


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