The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT 3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT 3AR.
Bibliographical noteFunding Information:
This research was supported by the Swiss National Science Foundation (SNSF-professorship PP00P2_123536 to ML), the EPSRC (EP/E042139/1) and the Wellcome Trust (085141 (CNC and JDH) and 081925/Z/07/Z (SCRL and AJT)). SCRL is a Wellcome Trust Senior Research Fellow in Basic Biomedical Science.
- 5-HT receptor
- Cys-loop ligand-gated ion channels
- Fluorescent ligands
- In vivo imaging
- Radioligand binding