Hidroksiüre'nin Anlatılmamış hikayesi: Bacak ülserli 3 olgunun tedavisi

Jihane Abou Rahal; Rim S. Ishak; Zaher K. Otrock; Joseph E. Maakaron; Samer Ghosn; Ali T. Taher

doi:10.4274/Tjh.2012.0134

Hidroksiüre'nin Anlatılmamış hikayesi: Bacak ülserli 3 olgunun tedavisi

Translated title of the contribution: Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases

Jihane Abou Rahal, Rim S. Ishak, Zaher K. Otrock, Joseph E. Maakaron, Samer Ghosn, Ali T. Taher

Research output: Contribution to journal › Review article › peer-review

Abstract

Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

Translated title of the contribution	Successful management of hydroxyurea-induced leg ulcers in essential thrombocythemia: Report of 3 cases
Original language	Turkish
Pages (from-to)	184-187
Number of pages	4
Journal	Turkish Journal of Hematology
Volume	30
Issue number	2
DOIs	https://doi.org/10.4274/Tjh.2012.0134
State	Published - 2013
Externally published	Yes

Keywords

Essential thrombocythemia
Hydroxyurea
Interferon
Leg ulcers

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10.4274/Tjh.2012.0134

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@article{79335ad884b64d2a84e93329d45767e2,

title = "Hidroksi{\"u}re'nin Anlatılmamı{\c s} hikayesi: Bacak {\"u}lserli 3 olgunun tedavisi",

abstract = "Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.",

keywords = "Essential thrombocythemia, Hydroxyurea, Interferon, Leg ulcers",

author = "Rahal, {Jihane Abou} and Ishak, {Rim S.} and Otrock, {Zaher K.} and Maakaron, {Joseph E.} and Samer Ghosn and Taher, {Ali T.}",

year = "2013",

doi = "10.4274/Tjh.2012.0134",

language = "Turkish",

volume = "30",

pages = "184--187",

journal = "Turkish Journal of Hematology",

issn = "1300-7777",

publisher = "Aves",

number = "2",

}

TY - JOUR

T1 - Hidroksiüre'nin Anlatılmamış hikayesi

T2 - Bacak ülserli 3 olgunun tedavisi

AU - Rahal, Jihane Abou

AU - Ishak, Rim S.

AU - Otrock, Zaher K.

AU - Maakaron, Joseph E.

AU - Ghosn, Samer

AU - Taher, Ali T.

PY - 2013

Y1 - 2013

N2 - Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

AB - Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications. Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.

KW - Essential thrombocythemia

KW - Hydroxyurea

KW - Interferon

KW - Leg ulcers

UR - http://www.scopus.com/inward/record.url?scp=84879162525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879162525&partnerID=8YFLogxK

U2 - 10.4274/Tjh.2012.0134

DO - 10.4274/Tjh.2012.0134

M3 - Review article

AN - SCOPUS:84879162525

SN - 1300-7777

VL - 30

SP - 184

EP - 187

JO - Turkish Journal of Hematology

JF - Turkish Journal of Hematology

IS - 2

ER -

Hidroksiüre'nin Anlatılmamış hikayesi: Bacak ülserli 3 olgunun tedavisi

Abstract

Keywords

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