Hidroacanthoma simplex: An ultrastructural and immunohistochemical study

Charles Perniciaro, Sigfrid A. Muller, Brian D. Zelickson, John L. Snow

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A representative case of hidroacanthoma simplex was studied with routine light microscopy, immunohistochemistry, and electron microscopy. Staining with the periodic acid‐Schffi reagent and immunostaining with anti‐keratin antibodies were useful in demarcating the tumor cells from adjacent normal epithelium. However, antibodies to carcinoembryonic antigen and epithelial membrane antigen did not help us to segregate or identify the neoplastic cells. Electron microscopy revealed tumor cells markedly different in appearance from luminal cells of the acrosyringium. Hidroacanthoma simplex does not appear to be derived from luminal cells of the acrosyringium. We propose criteria for the histologic diagnosis of this benign neoplasm.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalJournal of cutaneous pathology
Issue number3
StatePublished - Jun 1994
Externally publishedYes


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