Hidden IgA subclass determinants in human renal disease

T. R. Melvin; Y. Kim; M. E. Conley; D. L. Delacroix; A. F. Michael

doi:10.1038/ki.1985.65

Hidden IgA subclass determinants in human renal disease

T. R. Melvin, Y. Kim, M. E. Conley, D. L. Delacroix, A. F. Michael

Pediatrics - Nephrology

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Antibodies specific for different regions of the IgA₁ molecule were used to evaluate tissue from patients with systemic lupus erythematosus (SLE), IgA nephropathy (IgAN), idiopathic membranous nephropathy (IMN), and anti-glomerular basement membrane (GBM) nephritis. One of the IgA₁ epitopes was 'masked' in subepithelial and linear BM deposits but was detected in mesangial/subendothelial deposits. This epitope was also hidden following binding of IgA₁ antinuclear antibodies (ANA) to nuclear substrates, in vitro. The presence of IgA₁ in all loci was confirmed by reactivity of two other monoclonal anti-IgA₁ antibodies.

Original language	English (US)
Pages (from-to)	685-689
Number of pages	5
Journal	Kidney international
Volume	27
Issue number	4
DOIs	https://doi.org/10.1038/ki.1985.65
State	Published - Jan 1 1985

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Melvin, T. R., Kim, Y., Conley, M. E., Delacroix, D. L., & Michael, A. F. (1985). Hidden IgA subclass determinants in human renal disease. Kidney international, 27(4), 685-689. https://doi.org/10.1038/ki.1985.65

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AU - Kim, Y.

AU - Conley, M. E.

AU - Delacroix, D. L.

AU - Michael, A. F.

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AB - Antibodies specific for different regions of the IgA1 molecule were used to evaluate tissue from patients with systemic lupus erythematosus (SLE), IgA nephropathy (IgAN), idiopathic membranous nephropathy (IMN), and anti-glomerular basement membrane (GBM) nephritis. One of the IgA1 epitopes was 'masked' in subepithelial and linear BM deposits but was detected in mesangial/subendothelial deposits. This epitope was also hidden following binding of IgA1 antinuclear antibodies (ANA) to nuclear substrates, in vitro. The presence of IgA1 in all loci was confirmed by reactivity of two other monoclonal anti-IgA1 antibodies.

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