Hidden IgA subclass determinants in human renal disease

T. R. Melvin, Y. Kim, M. E. Conley, D. L. Delacroix, A. F. Michael

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Abstract

Antibodies specific for different regions of the IgA1 molecule were used to evaluate tissue from patients with systemic lupus erythematosus (SLE), IgA nephropathy (IgAN), idiopathic membranous nephropathy (IMN), and anti-glomerular basement membrane (GBM) nephritis. One of the IgA1 epitopes was 'masked' in subepithelial and linear BM deposits but was detected in mesangial/subendothelial deposits. This epitope was also hidden following binding of IgA1 antinuclear antibodies (ANA) to nuclear substrates, in vitro. The presence of IgA1 in all loci was confirmed by reactivity of two other monoclonal anti-IgA1 antibodies.

Original languageEnglish (US)
Pages (from-to)685-689
Number of pages5
JournalKidney international
Volume27
Issue number4
DOIs
StatePublished - Jan 1 1985

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    Melvin, T. R., Kim, Y., Conley, M. E., Delacroix, D. L., & Michael, A. F. (1985). Hidden IgA subclass determinants in human renal disease. Kidney international, 27(4), 685-689. https://doi.org/10.1038/ki.1985.65