Heterogeneous binding and central nervous system distribution of the multitargeted kinase inhibitor ponatinib restrict orthotopic efficacy in a patient-derived xenograft model of glioblastoma

Janice K. Laramy, Minjee Kim, Shiv K. Gupta, Karen E. Parrish, Shuangling Zhang, Katrina K. Bakken, Brett L. Carlson, Ann C. Mladek, Daniel J. Ma, Jann N. Sarkaria, William F. Elmquist

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Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science