Heterogeneity of systemic inflammatory responses to periodontal therapy

Jan H. Behle, Michael H. Sedaghatfar, Ryan T. Demmer, Dana L. Wolf, Romanita Celenti, Moritz Kebschull, Paul B. Belusko, Miriam Herrera-Abreu, Evanthia Lalla, Panos N. Papapanou

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Aims: We investigated the effect of comprehensive periodontal therapy on the levels of multiple systemic inflammatory biomarkers. Material and Methods: Thirty patients with severe periodontitis received comprehensive periodontal therapy within a 6-week period. Blood samples were obtained at: 1-week pre-therapy (T1), therapy initiation (T2), treatment completion (T3), and 4 weeks thereafter (T4). We assessed the plasma concentrations of 19 biomarkers using multiplex assays, and serum IgG antibodies to periodontal bacteria using checkerboard immunoblotting. At T2 and T4, dental plaque samples were analysed using checkerboard hybridizations. Results: At T3, PAI-1, sE-selectin, sVCAM-1, MMP-9, myeloperoxidase, and a composite summary inflammatory score (SIS) were significantly reduced. However, only sE-selectin, sICAM, and serum amyloid P sustained a reduction at T4. Responses were highly variable: analyses of SIS slopes between baseline and T4 showed that approximately 1/3 and 1/4 of the patients experienced a marked reduction and a pronounced increase in systemic inflammation, respectively, while the remainder were seemingly unchanged. Changes in inflammatory markers correlated poorly with clinical, microbiological and serological markers of periodontitis. Conclusions: Periodontal therapy resulted in an overall reduction of systemic inflammation, but the responses were inconsistent across subjects and largely not sustainable. The determinants of this substantial heterogeneity need to be explored further.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalJournal of clinical periodontology
Volume36
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • Atherosclerotic vascular disease
  • Inflammatory mediators
  • Periodontal therapy
  • Systemic inflammation

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