The striatal dopamine system has long been studied in the context of reward learning, motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive behavioral states, as well as diseases like addiction, it is essential to understand the full complexity of dopamine neurons and the striatal systems they target. A growing number of studies are uncovering details of the heterogeneity in dopamine neuron subpopulations. Here, we review that work to synthesize current understanding of dopamine system heterogeneity across three levels, anatomical organization, functions in behavior, and modes of action, wherein we focus on signaling profiles and local mechanisms for modulation of dopamine release. Together, these studies reveal new and emerging dimensions of the striatal dopamine system, informing its contribution to dynamic motivational and decision-making processes.
Bibliographical noteFunding Information:
This work was supported by NIH grants DA007234 and DA042895. Figure was created with Biorender.com. We thank members of the Saunders lab, as well as Kurt Fraser, Frank Collins, and Jeffrey Bye for their thoughtful input on this manuscript.
© 2020 Wiley Periodicals, Inc.
- substantia nigra
- ventral tegmental area
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural