Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking

Anne L. Collins, Benjamin T. Saunders

Research output: Contribution to journalReview article

Abstract

The striatal dopamine system has long been studied in the context of reward learning, motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive behavioral states, as well as diseases like addiction, it is essential to understand the full complexity of dopamine neurons and the striatal systems they target. A growing number of studies are uncovering details of the heterogeneity in dopamine neuron subpopulations. Here, we review that work to synthesize current understanding of dopamine system heterogeneity across three levels, anatomical organization, functions in behavior, and modes of action, wherein we focus on signaling profiles and local mechanisms for modulation of dopamine release. Together, these studies reveal new and emerging dimensions of the striatal dopamine system, informing its contribution to dynamic motivational and decision-making processes.

Original languageEnglish (US)
Pages (from-to)1046-1069
Number of pages24
JournalJournal of Neuroscience Research
Volume98
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • accumbens
  • acetylcholine
  • dopamine
  • reward
  • striatum
  • substantia nigra
  • ventral tegmental area

PubMed: MeSH publication types

  • Journal Article
  • Review

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