Heterogeneity in leukemia cell populations: A clear rationale for use of combination protocols for ex vivo marrow purging

F. M. Uckun, S. Ramakrishnan, D. Haag, L. L. Houston

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Immunotoxins, conjugates of monoclonal antibodies with toxins (such as ricin), a portion of the toxin (such as ricin A-chain), or a hemitoxin (such as pokeweed antiviral protein [PAP](3-6)), are currently being investigated for their value as selective marrow-purging agents in autologous bone marrow transplantation (ABMT). The efficiency of immunotoxins is likely to depend upon the phenotype of the treated leukemia cells and the extent of heterogeneity in expression of the target antigen among the leukemic cell population. In the present study, we tried to further characterize leukemic cell clones that escaped treatment with immunotoxin. Studies were performed to evaluate the ex vivo efficiency of a combination of mafosfamid, a synthetic derivative of cyclophosphamide, and a human B cell-specific immunotoxin containing PAP (B43-PAP), to eradicate these cells.

Original languageEnglish (US)
Pages (from-to)462-464
Number of pages3
JournalTransplantation Proceedings
Volume17
Issue number1 I
StatePublished - Jan 1 1985

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