Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Adam J. de Smith; Kyle M. Walsh; Libby M. Morimoto; Stephen S. Francis; Helen M. Hansen; Soyoung Jeon; Semira Gonseth; Minhui Chen; Hanxiao Sun; Sandra Luna-Fineman; Federico Antillón; Verónica Girón; Alice Y. Kang; Ivan Smirnov; Xiaorong Shao; Todd P. Whitehead; Lisa F. Barcellos; Kent W. Jolly; Jasmine Healy; Caroline Laverdière; Daniel Sinnett; Jeffrey W. Taub; Jillian M. Birch; Pamela D. Thompson; Maria S. Pombo-de-Oliveira; Logan G. Spector; Andrew T. DeWan; Beth A. Mueller; Charleston Chiang; Catherine Metayer; Xiaomei Ma; Joseph L. Wiemels

doi:10.1038/s41375-019-0514-9

Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Adam J. de Smith, Kyle M. Walsh, Libby M. Morimoto, Stephen S. Francis, Helen M. Hansen, Soyoung Jeon, Semira Gonseth, Minhui Chen, Hanxiao Sun, Sandra Luna-Fineman, Federico Antillón, Verónica Girón, Alice Y. Kang, Ivan Smirnov, Xiaorong Shao, Todd P. Whitehead, Lisa F. Barcellos, Kent W. Jolly, Jasmine Healy, Caroline LaverdièreDaniel Sinnett, Jeffrey W. Taub, Jillian M. Birch, Pamela D. Thompson, Maria S. Pombo-de-Oliveira, Logan G. Spector, Andrew T. DeWan, Beth A. Mueller, Charleston Chiang, Catherine Metayer, Xiaomei Ma, Joseph L. Wiemels

Pediatric Epidemiology & Clinical Research

Research output: Contribution to journal › Letter › peer-review

10 Scopus citations

Original language	English (US)
Pages (from-to)	2746-2751
Number of pages	6
Journal	Leukemia
Volume	33
Issue number	11
DOIs	https://doi.org/10.1038/s41375-019-0514-9
State	Published - Nov 1 2019

Bibliographical note

Funding Information:
Funding This study was supported by Alex’s Lemonade Stand Foundation “A” Awards (A.J.D., K.M.W.), the Emerging Investigator Fellowship Grant from the Pediatric Cancer Research Foundation (A.J.D.), The Children’s Health and Discovery Initiative of Translating Duke Health (K.M.W.), and research grants from the National Institutes of Health (R01 CA155461 to J.L.W. and X.M., R01 ES009137 to C.M., P24ES004705 to C.M., R24ES028524 to C.M. and L.M., and R21 ES021819 to L.M.). The 2016–2019 CLIC Scientific Annual Meetings were supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number U13ES026496. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The collection of cancer incidence data used in the CCRLP study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries, under cooperative agreement 5NU58DP003862–04/DP003862; the National Cancer Institute’s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California, and contract HHSN261201000034C awarded to the Public Health Institute.

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de Smith, A. J., Walsh, K. M., Morimoto, L. M., Francis, S. S., Hansen, H. M., Jeon, S., Gonseth, S., Chen, M., Sun, H., Luna-Fineman, S., Antillón, F., Girón, V., Kang, A. Y., Smirnov, I., Shao, X., Whitehead, T. P., Barcellos, L. F., Jolly, K. W., Healy, J., ... Wiemels, J. L. (2019). Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome. Leukemia, 33(11), 2746-2751. https://doi.org/10.1038/s41375-019-0514-9

de Smith, AJ, Walsh, KM, Morimoto, LM, Francis, SS, Hansen, HM, Jeon, S, Gonseth, S, Chen, M, Sun, H, Luna-Fineman, S, Antillón, F, Girón, V, Kang, AY, Smirnov, I, Shao, X, Whitehead, TP, Barcellos, LF, Jolly, KW, Healy, J, Laverdière, C, Sinnett, D, Taub, JW, Birch, JM, Thompson, PD, Pombo-de-Oliveira, MS, Spector, LG, DeWan, AT, Mueller, BA, Chiang, C, Metayer, C, Ma, X & Wiemels, JL 2019, 'Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome', Leukemia, vol. 33, no. 11, pp. 2746-2751. https://doi.org/10.1038/s41375-019-0514-9

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title = "Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome",

author = "{de Smith}, {Adam J.} and Walsh, {Kyle M.} and Morimoto, {Libby M.} and Francis, {Stephen S.} and Hansen, {Helen M.} and Soyoung Jeon and Semira Gonseth and Minhui Chen and Hanxiao Sun and Sandra Luna-Fineman and Federico Antill{\'o}n and Ver{\'o}nica Gir{\'o}n and Kang, {Alice Y.} and Ivan Smirnov and Xiaorong Shao and Whitehead, {Todd P.} and Barcellos, {Lisa F.} and Jolly, {Kent W.} and Jasmine Healy and Caroline Laverdi{\`e}re and Daniel Sinnett and Taub, {Jeffrey W.} and Birch, {Jillian M.} and Thompson, {Pamela D.} and Pombo-de-Oliveira, {Maria S.} and Spector, {Logan G.} and DeWan, {Andrew T.} and Mueller, {Beth A.} and Charleston Chiang and Catherine Metayer and Xiaomei Ma and Wiemels, {Joseph L.}",

note = "Funding Information: Funding This study was supported by Alex{\textquoteright}s Lemonade Stand Foundation “A” Awards (A.J.D., K.M.W.), the Emerging Investigator Fellowship Grant from the Pediatric Cancer Research Foundation (A.J.D.), The Children{\textquoteright}s Health and Discovery Initiative of Translating Duke Health (K.M.W.), and research grants from the National Institutes of Health (R01 CA155461 to J.L.W. and X.M., R01 ES009137 to C.M., P24ES004705 to C.M., R24ES028524 to C.M. and L.M., and R21 ES021819 to L.M.). The 2016–2019 CLIC Scientific Annual Meetings were supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number U13ES026496. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The collection of cancer incidence data used in the CCRLP study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention{\textquoteright}s (CDC) National Program of Cancer Registries, under cooperative agreement 5NU58DP003862–04/DP003862; the National Cancer Institute{\textquoteright}s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California, and contract HHSN261201000034C awarded to the Public Health Institute.",

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doi = "10.1038/s41375-019-0514-9",

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T1 - Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

AU - de Smith, Adam J.

AU - Walsh, Kyle M.

AU - Morimoto, Libby M.

AU - Francis, Stephen S.

AU - Hansen, Helen M.

AU - Jeon, Soyoung

AU - Gonseth, Semira

AU - Chen, Minhui

AU - Sun, Hanxiao

AU - Luna-Fineman, Sandra

AU - Antillón, Federico

AU - Girón, Verónica

AU - Kang, Alice Y.

AU - Smirnov, Ivan

AU - Shao, Xiaorong

AU - Whitehead, Todd P.

AU - Barcellos, Lisa F.

AU - Jolly, Kent W.

AU - Healy, Jasmine

AU - Laverdière, Caroline

AU - Sinnett, Daniel

AU - Taub, Jeffrey W.

AU - Birch, Jillian M.

AU - Thompson, Pamela D.

AU - Pombo-de-Oliveira, Maria S.

AU - Spector, Logan G.

AU - DeWan, Andrew T.

AU - Mueller, Beth A.

AU - Chiang, Charleston

AU - Metayer, Catherine

AU - Ma, Xiaomei

AU - Wiemels, Joseph L.

N1 - Funding Information: Funding This study was supported by Alex’s Lemonade Stand Foundation “A” Awards (A.J.D., K.M.W.), the Emerging Investigator Fellowship Grant from the Pediatric Cancer Research Foundation (A.J.D.), The Children’s Health and Discovery Initiative of Translating Duke Health (K.M.W.), and research grants from the National Institutes of Health (R01 CA155461 to J.L.W. and X.M., R01 ES009137 to C.M., P24ES004705 to C.M., R24ES028524 to C.M. and L.M., and R21 ES021819 to L.M.). The 2016–2019 CLIC Scientific Annual Meetings were supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number U13ES026496. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The collection of cancer incidence data used in the CCRLP study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries, under cooperative agreement 5NU58DP003862–04/DP003862; the National Cancer Institute’s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California, and contract HHSN261201000034C awarded to the Public Health Institute.

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SN - 0887-6924

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ER -

Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Bibliographical note

UN SDGs

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