Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart

William M. Grove; Elke D. Eckert; Leonard Heston; Thomas J. Bouchard; Nancy Segal; David T. Lykken

doi:10.1016/0006-3223(90)90500-2

Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart

William M. Grove
, Elke D. Eckert
, Leonard Heston
, Thomas J. Bouchard
, Nancy Segal
, David T. Lykken

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

Thirty-two sets of monozygotic twins reared apart since shortly after birth (31 pairs and one set of triplets; median age at separation was 0.2 years) were interviewed separately and blindly using the Diagnostic Interview Schedule for presence of DSM-III Axis I psychiatric disorders and antisocial personality. Because the sample was recruited from a nonclinical population, predictably few subjects met criteria for such disorders. However, items counting toward diagnoses were cumulated into four scores: alcohol-related problems, drug-related problems, childhood antisocial behavior, and adult antisocial behavior. The scores showed within-scale cohesion as measured by Cronbach's coefficient α. The drug scale and both antisocial scales showed significant heritability (p < 0.01), but the alcohol scale had an estimated heritability of zero (albeit with a broad confidence interval). There appeared to be substantial commonalities in the genetic factors responsible of these traits.

Original language	English (US)
Pages (from-to)	1293-1304
Number of pages	12
Journal	Biological Psychiatry
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(90)90500-2
State	Published - Jun 15 1990

Bibliographical note

Funding Information:
From the Departmentso f Psychiatry( W.M.G., E.D.E., L.H., D.T.L ) ~1Psychol.oK/,~r.J.B., N.S.), University of Miunesnta, Minneapolis, MN. Address reprint requests to William M. Grove, Ph.D., Department of Psychiatry, Box ~93 Mayo, University of Minnesota, Minneapolis, MN 55455. This research has been supported by grants from the Universityo f MinnesotaG raduate ~hoo! I~ ~h Charitable Foundation, the Spencer Foundation, the National Science Foundation (BNS.7926654), the Pioneer Fund, and the Han~ourt Brace Jovanovich Publishing Compeny. Received May 26, 1989; revised September 26, 1989.

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title = "Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart",

abstract = "Thirty-two sets of monozygotic twins reared apart since shortly after birth (31 pairs and one set of triplets; median age at separation was 0.2 years) were interviewed separately and blindly using the Diagnostic Interview Schedule for presence of DSM-III Axis I psychiatric disorders and antisocial personality. Because the sample was recruited from a nonclinical population, predictably few subjects met criteria for such disorders. However, items counting toward diagnoses were cumulated into four scores: alcohol-related problems, drug-related problems, childhood antisocial behavior, and adult antisocial behavior. The scores showed within-scale cohesion as measured by Cronbach's coefficient α. The drug scale and both antisocial scales showed significant heritability (p < 0.01), but the alcohol scale had an estimated heritability of zero (albeit with a broad confidence interval). There appeared to be substantial commonalities in the genetic factors responsible of these traits.",

author = "Grove, \{William M.\} and Eckert, \{Elke D.\} and Leonard Heston and Bouchard, \{Thomas J.\} and Nancy Segal and Lykken, \{David T.\}",

note = "Funding Information: From the Departmentso f Psychiatry( W.M.G., E.D.E., L.H., D.T.L ) \textasciitilde{}1Psychol.oK/,\textasciitilde{}r.J.B., N.S.), University of Miunesnta, Minneapolis, MN. Address reprint requests to William M. Grove, Ph.D., Department of Psychiatry, Box \textasciitilde{}93 Mayo, University of Minnesota, Minneapolis, MN 55455. This research has been supported by grants from the Universityo f MinnesotaG raduate \textasciitilde{}hoo! I\textasciitilde{} \textasciitilde{}h Charitable Foundation, the Spencer Foundation, the National Science Foundation (BNS.7926654), the Pioneer Fund, and the Han\textasciitilde{}ourt Brace Jovanovich Publishing Compeny. Received May 26, 1989; revised September 26, 1989.",

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Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart

Abstract

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