Heritability of brain neurovascular coupling

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1 Scopus citations

Abstract

The moment-to-moment variation of neurovascular coupling in the brain was determined by computing the moment-to-moment turnover of the blood-oxygen-level-dependent signal (TBOLD) at resting state. Here we show that 1) TBOLD is heritable, 2) its heritability estimates are highly correlated between left and right hemispheres, and 3) the degree of its heritability is determined, in part, by the anatomical proximity of the brain areas involved. We also show that the regional distribution of TBOLD in the cortex is significantly associated with that of the vesicular acetylcholine transporter. These findings establish that TBOLD as a key heritable measure of local cortical brain function captured by neurovascular coupling. NEW & NOTEWORTHY Here we show that the sample-to-sample turnover of the resting state fMRI blood-oxygen-level-dependent turnover (TBOLD) is heritable, the left and right hemisphere TBOLD heritabilities are highly correlated, and TBOLD heritability varies among cortical areas. Moreover, we documented that TBOLD is associated with the regional cortical distribution of the vesicular acetylcholine transporter.

Original languageEnglish (US)
Pages (from-to)1307-1311
Number of pages5
JournalJournal of neurophysiology
Volume128
Issue number5
DOIs
StatePublished - Nov 2022

Bibliographical note

Funding Information:
Partial funding for this study was provided by the McKnight Presidential Chair of Cognitive Neuroscience, the American Legion Brain Sciences Chair), and the U.S. Department of Veterans Affairs.

Funding Information:
Data are publicly available from the websites mentioned in the MATERIALS AND METHODS. Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kâmil Uğurbil; 1U54MH091657) funded by the 16 National Institutes of Health (NIH) institutes and centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.

Publisher Copyright:
© 2022 American Physiological Society. All rights reserved.

Keywords

  • blood oxygen level dependent turnover
  • fMRI
  • heritability
  • resting-state functional MRI
  • TBOLD
  • Vesicular Acetylcholine Transport Proteins
  • Brain
  • Magnetic Resonance Imaging
  • Oxygen
  • Neurovascular Coupling
  • Brain Mapping

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

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