Heritability and molecular-genetic basis of the P3 event-related brain potential: A genome-wide association study

Stephen M. Malone, Uma Vaidyanathan, Saonli Basu, Michael B. Miller, Matt Mcgue, William G. Iacono

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

P3 amplitude is a candidate endophenotype for disinhibitory psychopathology, psychosis, and other disorders. The present study is a comprehensive analysis of the behavioral- and molecular-genetic basis of P3 amplitude and a P3 genetic factor score in a large community sample (N=4,211) of adolescent twins and their parents, genotyped for 527,829 single nucleotide polymorphisms (SNPs). Biometric models indicated that as much as 65% of the variance in each measure was due to additive genes. All SNPs in aggregate accounted for approximately 40% to 50% of the heritable variance. However, analyses of individual SNPs did not yield any significant associations. Analyses of individual genes did not confirm previous associations between P3 amplitude and candidate genes but did yield a novel association with myelin expression factor 2 (MYEF2). Main effects of individual variants may be too small to be detected by GWAS without larger samples.

Original languageEnglish (US)
Pages (from-to)1246-1258
Number of pages13
JournalPsychophysiology
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Endophenotype
  • GCTA
  • Gene-based tests
  • Genome-wide association study
  • Heritability
  • Molecular genetics
  • P300

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