Heritability and molecular genetic basis of electrodermal activity: A genome-wide association study

Uma Vaidyanathan, Joshua D. Isen, Stephen M. Malone, Michael B. Miller, Matt Mcgue, William G. Iacono

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The molecular genetic basis of electrodermal activity (EDA) was analyzed using 527,829 single nucleotide polymorphisms (SNPs) in a large population-representative sample of twins and parents (N=4,424) in relation to various EDA indices. Biometric analyses suggested that approximately 50% or more of variance in all EDA indices was heritable. The combined effect of all SNPs together accounted for a significant amount of variance in each index, affirming their polygenic basis and heritability. However, none of the SNPs were genome-wide significant for any EDA index. Previously reported SNP associations with disorders such as substance dependence or schizophrenia, which have been linked to EDA abnormalities, were not significant; nor were associations between EDA and genes in specific neurotransmitter systems. These results suggest that EDA is influenced by multiple genes rather than by polymorphisms with large effects.

Original languageEnglish (US)
Pages (from-to)1259-1271
Number of pages13
JournalPsychophysiology
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Electrodermal activity
  • Genome-wide association study
  • Habituation
  • Heritability
  • Molecular genetics
  • Skin conductance

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