Hereditary esophageal dysfunction in the Miniature Schnauzer dog.

V. S. Cox, L. J. Wallace, V. E. Anderson, R. A. Rushmer

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Miniature Schnauzers maintained in a colony for 9 years were used to study the inheritance of esophageal dysfunction (canine achalasia, megaesophagus). All dogs were evaluated radiographically, using a barium swallow contrast technique which clearly distinguished normal and affected pups. At 4 to 6 months of age, all affected dogs had recovered clinically except one, and radiographic evidence of dysfunction was markedly diminished. None of the affected dogs required a special feeding regimen. Analysis of breeding pairs revealed a ratio of 9 affected/11 normal dogs when an affected male was mated with a normal female, and a 13/3 ratio was observed when two affected dogs were mated. These ratios were compatible with a simple autosomal dominant or a 60% penetrance autosomal-recessive mode of inheritance. Outbreeding to an affected Miniature Schnauzer/Poodle crossbred dog resulted in only two of 30 affected pups, indicating a polygenic mode of inheritance in outbred populations.

Original languageEnglish (US)
Pages (from-to)326-330
Number of pages5
JournalAmerican journal of veterinary research
Volume41
Issue number3
StatePublished - Mar 1 1980

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