Hepatoprotective activity of Caesalpinia bonducella seeds on paracetamol induced hepatotoxicity in male Albino rats

R. Parthasarathy, M. Nivethetha, P. Brindha

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Caesalpinia bonducella - seeds, an Ayurvedic drug source is studied for its hepatoprotective potentials and the results obtained are discussed. In the present work Hepatotoxicity is induced using Paracetamol. Animal model selected are male Albino rats. The alcohol extract of Caesalpinia bonducella seeds were prepared and administered at various dose levels (100, 150 and 300 mg/kg) to the induced rats. After 15 days the rats were sacrificed by cervical decapitation and the blood was collected to estimate the amount of Protein, Bilirubin, SGOT, SGPT and ALP. The liver homogenate was used to assess the activities of the membrane bound ATPases. The altered levels of the parameters were brought back to normal on treatment. From the results it is proved that the plant possess significant hepatoprotective activity at a dose level of 300 mg/kg body weight.

Original languageEnglish (US)
Pages (from-to)401-404
Number of pages4
JournalIndian Drugs
Volume44
Issue number5
StatePublished - May 1 2007
Externally publishedYes

Keywords

  • ALP
  • Bilirubin
  • Ca ATPase and Mg ATPase
  • Caesalpinia bonducella
  • Hepatoprotectivity
  • Na /K ATPase
  • Paracetamol
  • SGOT
  • SGPT
  • Total protein

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