Abstract
A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.
Original language | English (US) |
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Pages (from-to) | 892-894 |
Number of pages | 3 |
Journal | Science |
Volume | 192 |
Issue number | 4242 |
DOIs | |
State | Published - 1976 |