Abstract
A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 892-894 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 192 |
| Issue number | 4242 |
| DOIs | |
| State | Published - Jan 1 1976 |
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Hepatocellular transplantation for metabolic deficiencies : Decrease of plasma bilirubin in Gunn rats. / Matas, Arthur J.; Sutherland, David E R; Steffes, Michael W.; Michael Mauer, S.; Lowe, Ann; Simmons, Richard L.; Najarian, John S.
In: Science, Vol. 192, No. 4242, 01.01.1976, p. 892-894.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatocellular transplantation for metabolic deficiencies
T2 - Decrease of plasma bilirubin in Gunn rats
AU - Matas, Arthur J.
AU - Sutherland, David E R
AU - Steffes, Michael W.
AU - Michael Mauer, S.
AU - Lowe, Ann
AU - Simmons, Richard L.
AU - Najarian, John S.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.
AB - A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.
UR - http://www.scopus.com/inward/record.url?scp=0017062465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017062465&partnerID=8YFLogxK
U2 - 10.1126/science.818706
DO - 10.1126/science.818706
M3 - Article
C2 - 818706
AN - SCOPUS:0017062465
VL - 192
SP - 892
EP - 894
JO - Science
JF - Science
SN - 0036-8075
IS - 4242
ER -