Hepatocellular transplantation for metabolic deficiencies: Decrease of plasma bilirubin in Gunn rats

Arthur J. Matas; David E R Sutherland; Michael W. Steffes; S. Michael Mauer; Ann Lowe; Richard L. Simmons; John S. Najarian

doi:10.1126/science.818706

Hepatocellular transplantation for metabolic deficiencies: Decrease of plasma bilirubin in Gunn rats

Arthur J. Matas, David E R Sutherland, Michael W. Steffes, S. Michael Mauer, Ann Lowe, Richard L. Simmons, John S. Najarian

Research output: Contribution to journal › Article › peer-review

261 Scopus citations

Abstract

A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

Original language	English (US)
Pages (from-to)	892-894
Number of pages	3
Journal	Science
Volume	192
Issue number	4242
DOIs	https://doi.org/10.1126/science.818706
State	Published - 1976

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title = "Hepatocellular transplantation for metabolic deficiencies: Decrease of plasma bilirubin in Gunn rats",

abstract = "A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.",

author = "Matas, {Arthur J.} and Sutherland, {David E R} and Steffes, {Michael W.} and {Michael Mauer}, S. and Ann Lowe and Simmons, {Richard L.} and Najarian, {John S.}",

year = "1976",

doi = "10.1126/science.818706",

language = "English (US)",

volume = "192",

pages = "892--894",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

number = "4242",

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T1 - Hepatocellular transplantation for metabolic deficiencies

T2 - Decrease of plasma bilirubin in Gunn rats

AU - Matas, Arthur J.

AU - Sutherland, David E R

AU - Steffes, Michael W.

AU - Michael Mauer, S.

AU - Lowe, Ann

AU - Simmons, Richard L.

AU - Najarian, John S.

PY - 1976

Y1 - 1976

N2 - A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

AB - A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

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