Hepatocellular transplantation for metabolic deficiencies

Decrease of plasma bilirubin in Gunn rats

Arthur J. Matas, David E R Sutherland, Michael W. Steffes, S. Michael Mauer, Ann Lowe, Richard L. Simmons, John S. Najarian

Research output: Contribution to journalArticle

252 Citations (Scopus)

Abstract

A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme undine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

Original languageEnglish (US)
Pages (from-to)892-894
Number of pages3
JournalScience
Volume192
Issue number4242
DOIs
StatePublished - Jan 1 1976

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Gunn Rats
Bilirubin
Transplantation
Enzymes
Enzyme Therapy
Deficiency Diseases
Glucuronosyltransferase
Diphosphates
Cell Transplantation
Portal Vein
Hepatocytes

Cite this

Hepatocellular transplantation for metabolic deficiencies : Decrease of plasma bilirubin in Gunn rats. / Matas, Arthur J.; Sutherland, David E R; Steffes, Michael W.; Michael Mauer, S.; Lowe, Ann; Simmons, Richard L.; Najarian, John S.

In: Science, Vol. 192, No. 4242, 01.01.1976, p. 892-894.

Research output: Contribution to journalArticle

Matas, Arthur J. ; Sutherland, David E R ; Steffes, Michael W. ; Michael Mauer, S. ; Lowe, Ann ; Simmons, Richard L. ; Najarian, John S. / Hepatocellular transplantation for metabolic deficiencies : Decrease of plasma bilirubin in Gunn rats. In: Science. 1976 ; Vol. 192, No. 4242. pp. 892-894.
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