Hepatocellular carcinoma-the role of the underlying liver disease in clinical practice

Angelo Zambam de Mattos, Isadora Zanotelli Bombassaro, Arndt Vogel, Jose D. Debes

Research output: Contribution to journalReview articlepeer-review


Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality. This particular type of cancer has the distinctive characteristic of mostly happening in individuals with an underlying liver disease. This makes the management of patients more challenging, since physicians must take into consideration two different conditions, the chronic liver disease and the tumor. The underlying liver disease has several implications in clinical practice, because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC, obstacles in surveillance, and differences in the efficacy of the treatment against HCC. A shift in the prevalence of liver diseases has been evident over the last few years, with viral hepatitis gradually losing the leading position as cause of HCC and metabolic dysfunction-associated steatotic liver disease gaining importance. Therefore, in an era of personalized medicine, it is imperative that physicians are aware of the underlying liver disease of individuals with HCC and its impact in the management of their tumors.

Original languageEnglish (US)
Pages (from-to)2488-2495
Number of pages8
JournalWorld journal of gastroenterology
Issue number19
StatePublished - May 21 2024

Bibliographical note

Publisher Copyright:
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.


  • Epidemiology
  • Etiology
  • Hepatocellular carcinoma
  • Surveillance
  • Therapy

PubMed: MeSH publication types

  • Review
  • Journal Article
  • Editorial


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