Abstract
Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 142-146 |
| Number of pages | 5 |
| Journal | Annals of Hepatology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Hepatocellular carcinoma
- Iron overload
- Liver iron concentration
- Risk factor
- Thalassemia intermedia
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