TY - JOUR
T1 - Hepatitis E virus infection in the HIV-positive patient
AU - Debes, Jose D.
AU - Pisano, Maria Belen
AU - Lotto, Martin
AU - Re, Viviana
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Hepatitis E virus (HEV) is a RNA virus that can cause hepatitis. In immunocompetent individuals, infection with HEV usually leads to asymptomatic seroconversion. However, in immunosuppressed patients, such as transplant recipients, HEV can develop into a chronic infection. Studies regarding the seroprevalence and clinical implications of HEV in patients infected with the human immunodeficiency virus (HIV) are conflicting. Levels of CD4 count in blood seem to be the most widely associated risk factor, while other factors such as meat consumption or proximity to animals are less clearly associated with HEV infection. Progression to chronicity, as well as extrahepatic manifestations of HEV seem rare in HIV, and the implications of HEV in liver disease progression are poorly understood in the HIV-infected. In this review we describe the epidemiology, risk factors, and clinical implications of HEV infection in individuals infected with HIV.
AB - Hepatitis E virus (HEV) is a RNA virus that can cause hepatitis. In immunocompetent individuals, infection with HEV usually leads to asymptomatic seroconversion. However, in immunosuppressed patients, such as transplant recipients, HEV can develop into a chronic infection. Studies regarding the seroprevalence and clinical implications of HEV in patients infected with the human immunodeficiency virus (HIV) are conflicting. Levels of CD4 count in blood seem to be the most widely associated risk factor, while other factors such as meat consumption or proximity to animals are less clearly associated with HEV infection. Progression to chronicity, as well as extrahepatic manifestations of HEV seem rare in HIV, and the implications of HEV in liver disease progression are poorly understood in the HIV-infected. In this review we describe the epidemiology, risk factors, and clinical implications of HEV infection in individuals infected with HIV.
KW - CD4 counts
KW - HIV
KW - Hepatitis E virus
KW - Risk factors
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U2 - 10.1016/j.jcv.2016.05.006
DO - 10.1016/j.jcv.2016.05.006
M3 - Review article
C2 - 27243210
AN - SCOPUS:84970028397
VL - 80
SP - 102
EP - 106
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
ER -