Hepatitis E virus infection in the HIV-positive patient

Jose D. Debes, Maria Belen Pisano, Martin Lotto, Viviana Re

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Hepatitis E virus (HEV) is a RNA virus that can cause hepatitis. In immunocompetent individuals, infection with HEV usually leads to asymptomatic seroconversion. However, in immunosuppressed patients, such as transplant recipients, HEV can develop into a chronic infection. Studies regarding the seroprevalence and clinical implications of HEV in patients infected with the human immunodeficiency virus (HIV) are conflicting. Levels of CD4 count in blood seem to be the most widely associated risk factor, while other factors such as meat consumption or proximity to animals are less clearly associated with HEV infection. Progression to chronicity, as well as extrahepatic manifestations of HEV seem rare in HIV, and the implications of HEV in liver disease progression are poorly understood in the HIV-infected. In this review we describe the epidemiology, risk factors, and clinical implications of HEV infection in individuals infected with HIV.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalJournal of Clinical Virology
StatePublished - Jul 1 2016

Bibliographical note

Funding Information:
Partially funded by American College of Gastroenterology, Clinical Research Award to JD.

Publisher Copyright:
© 2016 Elsevier B.V.


  • CD4 counts
  • HIV
  • Hepatitis E virus
  • Risk factors


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