Hepatitis b in ward and clinical laboratory employees of a general hospital

Levy, B. S. (128 Hollis St., Sherborn, MA 01770), J. C. Harris, J. L. Smith, J. W. Washburn, J. Mature, A. Davis, J. T. Crosson, H. Polesky and M. Hanson. Hepatitis B in ward and clinical laboratory employees of a general hospital. Am J Epidemiol 106:330-335, 1977.After a sharp increase in viral hepatitis cases, mostly type B, among the 2000 employees of a general hospital during three years, we conducted an investigation which consisted of obtaining data on employee cases and surveying many current employees. Of the 38 cases, 22 occurred in nonphysician, ward employees. Of 189 current ward employees, 8% had antibody to hepatitis B surface antigen (anti-HB₃) and 1% had hepatitis B surface antigen (HB₃Ag). Hepatitis B virus (HBV) seropositivity was highest for employees who worked closely with hemodialysis and renal transplant patients and for those who claimed that their ward was understaffed. Nine of the 38 cases occurred in clinical lab workers. Of 70 current lab employees, 17% were positive for anti-HB₃ and none for HB₃Ag. HBV seropositivity was highest for those working in the chemistry section (highest there among those performing blood-gas determinations and those working with the multi-channel autoanalyzers) and those who routinely got blood on their skin and clothes at work. All seropositive employees worked routinely with blood. These data support the hypotheses that many hospital employees contract hepatitis B from exposure to HB₃Ag-positive patients and many clinical laboratory employees contract it from exposure to HBV-contaminated blood.