Hepatic lipid droplet biology: Getting to the root of fatty liver

Douglas G. Mashek, Salmaan A. Khan, Aishwarya Sathyanarayan, Jonathan M. Ploeger, Mallory P. Franklin

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease.

Original languageEnglish (US)
Pages (from-to)964-967
Number of pages4
JournalHepatology
Volume62
Issue number3
DOIs
StatePublished - Sep 1 2015

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Fatty Liver
Liver
Lipids
Organelles
Liver Diseases
Hepatocytes
Lipid Droplets

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Mashek, D. G., Khan, S. A., Sathyanarayan, A., Ploeger, J. M., & Franklin, M. P. (2015). Hepatic lipid droplet biology: Getting to the root of fatty liver. Hepatology, 62(3), 964-967. https://doi.org/10.1002/hep.27839

Hepatic lipid droplet biology : Getting to the root of fatty liver. / Mashek, Douglas G.; Khan, Salmaan A.; Sathyanarayan, Aishwarya; Ploeger, Jonathan M.; Franklin, Mallory P.

In: Hepatology, Vol. 62, No. 3, 01.09.2015, p. 964-967.

Research output: Contribution to journalArticle

Mashek, DG, Khan, SA, Sathyanarayan, A, Ploeger, JM & Franklin, MP 2015, 'Hepatic lipid droplet biology: Getting to the root of fatty liver', Hepatology, vol. 62, no. 3, pp. 964-967. https://doi.org/10.1002/hep.27839
Mashek DG, Khan SA, Sathyanarayan A, Ploeger JM, Franklin MP. Hepatic lipid droplet biology: Getting to the root of fatty liver. Hepatology. 2015 Sep 1;62(3):964-967. https://doi.org/10.1002/hep.27839
Mashek, Douglas G. ; Khan, Salmaan A. ; Sathyanarayan, Aishwarya ; Ploeger, Jonathan M. ; Franklin, Mallory P. / Hepatic lipid droplet biology : Getting to the root of fatty liver. In: Hepatology. 2015 ; Vol. 62, No. 3. pp. 964-967.
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