Hepatic and intestinal 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in genetically diabetic mice

R. L. Gebhard, A. S. Levine, W. F. Prigge, D. M. Brown, B. S. Handwerger, J. E. Morley

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Cholesterol synthesis rate, as determined by 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, is characterized in the major organs of genetically diabetic mice. Both C57BL Ks db+ db+ and C57BL 6 ob+ ob+ mice are hyperinsulinemic and insulin-resistant. These animals demonstrate loss of the circadian rhythm of hepatic reductase activity and a tendency for increased intestinal activity. As a result, proportionally more endogenous cholesterol synthesis occurs in intestinal mucosa than liver in genetically diabetic animals. Thus, the alterations in activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase which are observed in animal models of diabetes are the result of diminished insulin effect rather than insulin level.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume113
Issue number2
DOIs
StatePublished - Jun 15 1983

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