Heparan Sulfate Proteoglycans in the Stem Cell Niche: Lessons from Drosophila

Nanako Bowden, Hiroshi Nakato

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In addition to the obvious importance of stem cells in regenerative medicine, their unique behaviors and ingenious molecular systems for their control are of particular interest in the context of basic cell biology. Drosophila genetics plays a pivotal role to reveal fundamental principles of stem cell control mechanisms. Namely, in vivo studies using lineage tracing techniques elucidated the cellular and molecular mechanisms of the interactions between stem cells and the extracellular microenvironment. As one of the key components of the stem cell niche, heparan sulfate proteoglycans (HSPGs) have critical functions in regulating stem cell behavior. HSPGs serve as co-receptors for numerous ligands such as fibroblast growth factors, bone morphogenetic proteins, Wnt-related factors, hedgehog, and cytokines, which are all imperative regulators of stem cell behaviors. By modulating and orchestrating these niche factors’ signaling and distribution, HSPGs control the quantity, quality, and activity of stem cells.

Original languageEnglish (US)
Title of host publicationBiology of Extracellular Matrix
PublisherSpringer Science and Business Media Deutschland GmbH
Pages1-19
Number of pages19
DOIs
StatePublished - 2021

Publication series

NameBiology of Extracellular Matrix
Volume9
ISSN (Print)0887-3224
ISSN (Electronic)2191-1959

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2021.

Keywords

  • Drosophila
  • Heparan sulfate proteoglycan
  • Stem cell niche

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