Hemodynamic effect of dobutamine in patients with severe heart failure

Nasim Akhtar, Esteban Mikulic, Jay N Cohn, M. Hafeez Chaudhry

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Abstract

Dobutamine, a derivative of dopamine, was infused at a rate of 10 μg/kg per min in 15 patients with severe congestive heart failure. Cardiac output increased from an average of 3.1 to 5.6 liters/min (P < 0.001) with no change in mean arterial pressure (93.3 to 98.2 mm Hg) and only a slight increase in heart rate (98.5 to 105.2 beats/min) (P < 0.02). Pulmonary wedge pressure was decreased from an average of 27.4 to 21.1 mm Hg (P < 0.001). In seven patients a dose of 5 μg/kg per min also produced a significant increase in cardiac output but the effect was less than with the 10 μg/kg per min dose. No side effects were observed during the infusion. Dobutamine therefore is a potent inotropic drug with limited chronotropic and peripheral vascular effects and deserves therapeutic trial in the short-term management of low output heart failure.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalThe American Journal of Cardiology
Volume36
Issue number2
DOIs
StatePublished - Aug 1975

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