Hemocompatible tissue-engineered vascular grafts using adult mesenchymal stem cells

Anh La; Robert T. Tranquillo

doi:10.1016/j.cobme.2018.02.001

Hemocompatible tissue-engineered vascular grafts using adult mesenchymal stem cells

Anh La, Robert T. Tranquillo

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Vascular tissue engineering can now produce compliant and durable vascular grafts to address limited supply of autologous vessel grafts for patients with coronary artery disease. Due to the demand for an anti-thrombogenic luminal surface, mesenchymal stem cells (MSCs) have been investigated for their potential to differentiate into an endothelial phenotype. This can be done through several types of chemical and biomechanical stimulation. Adipose-derived MSCs are of particular interest because they present an autologous source of sufficient MSCs to seed a monolayer onto the lumen of a typical coronary bypass graft. This review provides an overview of recent developments in endothelial differentiation methods of MSCs and main findings, as well as perspectives on future research.

Original language	English (US)
Pages (from-to)	66-73
Number of pages	8
Journal	Current Opinion in Biomedical Engineering
Volume	5
DOIs	https://doi.org/10.1016/j.cobme.2018.02.001
State	Published - Mar 2018

Keywords

Chemical factors
Cyclic stretching
Endothelial cells
Mesenchymal stem cells
Shear stress
Tissue-engineered vascular grafts

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10.1016/j.cobme.2018.02.001

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title = "Hemocompatible tissue-engineered vascular grafts using adult mesenchymal stem cells",

abstract = "Vascular tissue engineering can now produce compliant and durable vascular grafts to address limited supply of autologous vessel grafts for patients with coronary artery disease. Due to the demand for an anti-thrombogenic luminal surface, mesenchymal stem cells (MSCs) have been investigated for their potential to differentiate into an endothelial phenotype. This can be done through several types of chemical and biomechanical stimulation. Adipose-derived MSCs are of particular interest because they present an autologous source of sufficient MSCs to seed a monolayer onto the lumen of a typical coronary bypass graft. This review provides an overview of recent developments in endothelial differentiation methods of MSCs and main findings, as well as perspectives on future research.",

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T1 - Hemocompatible tissue-engineered vascular grafts using adult mesenchymal stem cells

AU - La, Anh

AU - Tranquillo, Robert T.

PY - 2018/3

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N2 - Vascular tissue engineering can now produce compliant and durable vascular grafts to address limited supply of autologous vessel grafts for patients with coronary artery disease. Due to the demand for an anti-thrombogenic luminal surface, mesenchymal stem cells (MSCs) have been investigated for their potential to differentiate into an endothelial phenotype. This can be done through several types of chemical and biomechanical stimulation. Adipose-derived MSCs are of particular interest because they present an autologous source of sufficient MSCs to seed a monolayer onto the lumen of a typical coronary bypass graft. This review provides an overview of recent developments in endothelial differentiation methods of MSCs and main findings, as well as perspectives on future research.

AB - Vascular tissue engineering can now produce compliant and durable vascular grafts to address limited supply of autologous vessel grafts for patients with coronary artery disease. Due to the demand for an anti-thrombogenic luminal surface, mesenchymal stem cells (MSCs) have been investigated for their potential to differentiate into an endothelial phenotype. This can be done through several types of chemical and biomechanical stimulation. Adipose-derived MSCs are of particular interest because they present an autologous source of sufficient MSCs to seed a monolayer onto the lumen of a typical coronary bypass graft. This review provides an overview of recent developments in endothelial differentiation methods of MSCs and main findings, as well as perspectives on future research.

KW - Chemical factors

KW - Cyclic stretching

KW - Endothelial cells

KW - Mesenchymal stem cells

KW - Shear stress

KW - Tissue-engineered vascular grafts

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DO - 10.1016/j.cobme.2018.02.001

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AN - SCOPUS:85048688399

SN - 2468-4511

VL - 5

SP - 66

EP - 73

JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

ER -

Hemocompatible tissue-engineered vascular grafts using adult mesenchymal stem cells

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Keywords

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