Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine

Kati Erdmann, Belinda W.Y. Cheung, Stephan Immenschuh, Henning Schröder

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The sulfur compound and dietary supplement S-adenosylmethionine (SAM) has been reported to have cytoprotective and antioxidant properties. However, the underlying mechanisms remain unresolved. The present study investigates the effect of SAM on the expression of the antioxidant stress proteins heme oxygenase-1 (HO-1) and ferritin in endothelial cells. Induction of the HO-1/ferritin-system leads to protection of tissues against several inflammatory stimuli. SAM increased the protein and mRNA levels of HO-1 in cultured endothelial cells. Induction of HO-1 gene expression was associated with elevated ferritin protein levels and regulated at the transcriptional level via increased promoter activity. HO-1 upregulation by SAM was causally related to a decrease in NADPH-mediated production of oxygen radicals. Our results demonstrate that the HO-1/ferritin-system is a novel target of the antioxidant compound SAM.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume368
Issue number4
DOIs
StatePublished - Apr 18 2008

Keywords

  • Antioxidant
  • Endothelial cells
  • Ferritin
  • Heme oxygenase-1
  • S-Adenosylmethionine

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