Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Zhijun Guo, Irina F. Sevrioukova, Ilia G. Denisov, Xia Zhang, Ting Lan Chiu, Dafydd G. Thomas, Eric A. Hanse, Rebecca A.D. Cuellar, Yelena V. Grinkova, Vanessa Wankhede Langenfeld, Daniel S. Swedien, Justin D. Stamschror, Juan Alvarez, Fernando Luna, Adela Galván, Young Kyung Bae, Julia D. Wulfkuhle, Rosa I. Gallagher, Emanuel F. Petricoin, Beverly NorrisCraig M. Flory, Robert J. Schumacher, M. Gerard O'Sullivan, Qing Cao, Haitao Chu, John D. Lipscomb, William M. Atkins, Kalpna Gupta, Ameeta Kelekar, Ian A. Blair, Jorge H. Capdevila, John R. Falck, Stephen G. Sligar, Thomas L. Poulos, Gunda I. Georg, Elizabeth Ambrose, David A. Potter

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Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology