Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

Christen L. Ebens; Smitha Hosahalli Vasanna; Diana Vilkama; Tamara C Pozos; Attila Kumánovics; Alison Hornyak; Amir A. Sadighi Akha

doi:10.70962/jhi.20250212

Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

Christen L. Ebens
, Smitha Hosahalli Vasanna
, Diana Vilkama
, Tamara C Pozos
, Attila Kumánovics
, Alison Hornyak
, Amir A. Sadighi Akha

Research output: Contribution to journal › Letter › peer-review

Abstract

This study demonstrates successful hematopoietic stem cell transplant of CD40L deficiency using an asymptomatic carrier mother, leading to sustained 32% CD40L expression, normal recovery of T and B cell development and diversity, and expected growth and development 7.5 years post-transplant.

Original language	English (US)
Article number	e20250212
Journal	Journal of Human Immunity
Volume	2
Issue number	3
DOIs	https://doi.org/10.70962/jhi.20250212
State	Published - May 3 2026

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© 2026 Ebens et al.

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title = "Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency",

abstract = "This study demonstrates successful hematopoietic stem cell transplant of CD40L deficiency using an asymptomatic carrier mother, leading to sustained 32\% CD40L expression, normal recovery of T and B cell development and diversity, and expected growth and development 7.5 years post-transplant.",

author = "Ebens, \{Christen L.\} and Vasanna, \{Smitha Hosahalli\} and Diana Vilkama and Pozos, \{Tamara C\} and Attila Kum{\'a}novics and Alison Hornyak and \{Sadighi Akha\}, \{Amir A.\}",

note = "Publisher Copyright: {\textcopyright} 2026 Ebens et al.",

year = "2026",

month = may,

day = "3",

doi = "10.70962/jhi.20250212",

language = "English (US)",

volume = "2",

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T1 - Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

AU - Ebens, Christen L.

AU - Vasanna, Smitha Hosahalli

AU - Vilkama, Diana

AU - Pozos, Tamara C

AU - Kumánovics, Attila

AU - Hornyak, Alison

AU - Sadighi Akha, Amir A.

PY - 2026/5/3

Y1 - 2026/5/3

N2 - This study demonstrates successful hematopoietic stem cell transplant of CD40L deficiency using an asymptomatic carrier mother, leading to sustained 32% CD40L expression, normal recovery of T and B cell development and diversity, and expected growth and development 7.5 years post-transplant.

AB - This study demonstrates successful hematopoietic stem cell transplant of CD40L deficiency using an asymptomatic carrier mother, leading to sustained 32% CD40L expression, normal recovery of T and B cell development and diversity, and expected growth and development 7.5 years post-transplant.

UR - https://www.scopus.com/pages/publications/105039325516

UR - https://www.scopus.com/pages/publications/105039325516#tab=citedBy

U2 - 10.70962/jhi.20250212

DO - 10.70962/jhi.20250212

M3 - Letter

C2 - 42169993

AN - SCOPUS:105039325516

SN - 3065-8993

VL - 2

JO - Journal of Human Immunity

JF - Journal of Human Immunity

IS - 3

M1 - e20250212

ER -

Hematopoietic stem cell transplant with a carrier donor rescues CD40L deficiency

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