Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies

Kanwaldeep Mallhi, Lawrence G. Lum, Kirk R. Schultz, Maxim Yankelevich

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.

Original languageEnglish (US)
Pages (from-to)257-273
Number of pages17
JournalPediatric Clinics of North America
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Adolescents
  • Cancer
  • Cellular therapy
  • Children
  • Hematopoietic cell transplantation

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