Abstract
Hematopoietic cell transplantation (HCT) represents the most common and effective form of immunotherapy for childhood malignancies. The role of the graft-versus-leukemia effect in allogeneic HCT has been well established in childhood malignancies, but is also associated with short-term and long-term morbidity. HCT may be ineffective in some settings at obtaining control of the malignancy, and as such, cannot be used as a universal cancer immunotherapy. Novel therapies using dendritic cell vaccinations, tumor-infiltrating lymphocytes, and chimeric antigen receptor T cells are being evaluated as potential adjuvants to HCT.
Original language | English (US) |
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Pages (from-to) | 257-273 |
Number of pages | 17 |
Journal | Pediatric clinics of North America |
Volume | 62 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Elsevier Inc.
Keywords
- Adolescents
- Cancer
- Cellular therapy
- Children
- Hematopoietic cell transplantation