Hematin toxicity in rats

D. L. Lips; C. A. Pierach; P. S. Edwards

doi:10.1016/0378-4274(78)90034-6

Hematin toxicity in rats

D. L. Lips
, C. A. Pierach
, P. S. Edwards

Medicine - Administration

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The toxicity of intravenously administered hematin (3.4 and 6 mg 100 g) was investigated in rats, where an LD₅₀ of 4.32 mg 100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg 100 g. At toxic levels (4 mg 100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated. This study indicates a possibly wide therapeutic margin of safety, when compared to the therapeutic use of hematin on porphyric patients.

Original language	English (US)
Pages (from-to)	329-332
Number of pages	4
Journal	Toxicology Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/0378-4274(78)90034-6
State	Published - Dec 1978

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title = "Hematin toxicity in rats",

abstract = "The toxicity of intravenously administered hematin (3.4 and 6 mg 100 g) was investigated in rats, where an LD50 of 4.32 mg 100 g was computed, with 95\% confidence limits of 5.40 and 3.46 mg 100 g. At toxic levels (4 mg 100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated. This study indicates a possibly wide therapeutic margin of safety, when compared to the therapeutic use of hematin on porphyric patients.",

author = "Lips, \{D. L.\} and Pierach, \{C. A.\} and Edwards, \{P. S.\}",

year = "1978",

month = dec,

doi = "10.1016/0378-4274(78)90034-6",

language = "English (US)",

volume = "2",

pages = "329--332",

journal = "Toxicology Letters",

issn = "0378-4274",

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number = "6",

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TY - JOUR

T1 - Hematin toxicity in rats

AU - Lips, D. L.

AU - Pierach, C. A.

AU - Edwards, P. S.

PY - 1978/12

Y1 - 1978/12

N2 - The toxicity of intravenously administered hematin (3.4 and 6 mg 100 g) was investigated in rats, where an LD50 of 4.32 mg 100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg 100 g. At toxic levels (4 mg 100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated. This study indicates a possibly wide therapeutic margin of safety, when compared to the therapeutic use of hematin on porphyric patients.

AB - The toxicity of intravenously administered hematin (3.4 and 6 mg 100 g) was investigated in rats, where an LD50 of 4.32 mg 100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg 100 g. At toxic levels (4 mg 100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated. This study indicates a possibly wide therapeutic margin of safety, when compared to the therapeutic use of hematin on porphyric patients.

UR - https://www.scopus.com/pages/publications/0018124163

UR - https://www.scopus.com/pages/publications/0018124163#tab=citedBy

U2 - 10.1016/0378-4274(78)90034-6

DO - 10.1016/0378-4274(78)90034-6

M3 - Article

AN - SCOPUS:0018124163

SN - 0378-4274

VL - 2

SP - 329

EP - 332

JO - Toxicology Letters

JF - Toxicology Letters

IS - 6

ER -

Hematin toxicity in rats

Abstract

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