Hematin toxicity in rats

D. L. Lips, C. A. Pierach, P. S. Edwards

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The toxicity of intravenously administered hematin (3.4 and 6 mg 100 g) was investigated in rats, where an LD50 of 4.32 mg 100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg 100 g. At toxic levels (4 mg 100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated. This study indicates a possibly wide therapeutic margin of safety, when compared to the therapeutic use of hematin on porphyric patients.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalToxicology Letters
Volume2
Issue number6
DOIs
StatePublished - Dec 1978

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