Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

Keyphrases

• Hemangiosarcoma 100%
• Cancer Stem Cells 100%
• Targeted Toxin 100%
• Epidermal Growth Factor Receptor 100%
• Soluble Urokinase Plasminogen Activator Receptor (suPAR) 100%
• Stem Cell Subpopulation 100%
• Sarcoma 75%
• Cytotoxicity 75%
• Companion Animals 50%
• Canine Hemangiosarcoma 50%
• Bispecific 50%
• Translational Development 50%
• Ligand-targeted 50%
• Chemoresistant 50%
• Epidermal Growth Factor 50%
• Cell-derived 50%
• Urokinase 50%
• Pseudomonas Exotoxin 50%
• Radioresistant Tumors 50%
• Treatment Options 25%
• Cancer Cells 25%
• Clinical Development 25%
• Cell Population 25%
• Acquired Resistance 25%
• Frog 25%
• Chemotherapy Resistance 25%
• Order of Magnitude 25%
• Sarcoma Cells 25%
• IC50 25%
• Threshold Level 25%
• Canine Tumors 25%
• Drug-resistant Tumor 25%
• Cytotoxic Agents 25%
• Intrinsic Resistance 25%
• Cancer Stem Cell Model 25%
• Domestic Dog 25%
• Cytotoxic Molecules 25%
• Ligand-receptor Interaction 25%
• EGFR Expression 25%
• Specific Ligands 25%
• Animal Tumors 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Angiosarcoma 100%
• Epidermal Growth Factor Receptor 100%
• Urokinase Receptor 100%
• Connective Tissue Cancer 66%
• Canis 50%
• Cytotoxicity 50%
• Pseudomonas Exotoxin 33%
• Epidermal Growth Factor 33%
• Urokinase 33%
• Chemotherapy 16%
• Anura 16%
• Receptor 16%
• IC50 16%
• Neoplasm 16%
• Cytotoxic Agent 16%

Veterinary Science and Veterinary Medicine

• Stem Cell 100%
• Epidermal Growth Factor 100%
• Angiosarcoma 100%
• Cancer 100%
• Connective Tissue Cancer 80%
• Tumor 60%
• Pseudomonas 40%
• Canine Hemangiosarcoma 40%
• Dog 20%
• Cancer Cell 20%
• Neoplasm 20%
• Canine Tumors 20%