Infection and diagnosis with HPV create significant support needs, yet the support experiences and evaluations of women with HPV remain unexplored. This study identified supportive communication behavior perceived as helpful or problematic by women with HPV. Interviews with 25 participants revealed that women find it helpful when supportive others: (a) provide reassurance, information, and validation; (b) attend appointments; (c) facilitate reappraisals; and, (d) listen. Findings also highlighted support challenges, such as disclosure difficulties and problems locating and accessing support groups. The discussion focuses on explanations for and implications of variations in enacted support quality for women with HPV and others managing chronic illnesses.