Height and risk of incident intraparenchymal hemorrhage: Atherosclerosis risk in communities and cardiovascular health study cohorts

Lindsay G. Smith, Hiroshi Yatsuya, Bruce M. Psaty, W. T. Longstreth, Aaron R. Folsom

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Height is inversely associated with incident coronary disease and total stroke, but few studies have examined the association between height and intraparenchymal hemorrhage (IPH). We hypothesized that height would be inversely associated with incident IPH in the combined cohorts of the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Methods: Data on Caucasian and African American participants were used to estimate the association of height at baseline with incident IPH verified by clinician review of medical records and imaging reports. Sex-specific Cox proportional hazards regression models were used to calculate hazard ratios. Results: A total of 20,983 participants initially free of stroke (11,788 women and 9195 men) were followed for an average of 15.9 years (standard deviation [SD] 5.1 years). Incident IPH occurred in 115 women and 73 men. Sex, but not age, race, study, or blood pressure, modified the association (P =.03). After adjustment for risk factors (age, systolic blood pressure, triglycerides, low-density lipoprotein cholesterol, fibrinogen, and race), among women, height was significantly inversely associated with incident IPH (hazard ratio [HR] per SD [6.3 cm] was 0.81; 95% confidence interval [CI] 0.66-0.99; P =.04). The HR for tertile 3 vs 1 in women was 0.63 (95% CI 0.37-1.08). Among men, height was not linearly associated with incident IPH (HR per SD [6.7 cm] was 1.09; 95% CI 0.84-1.40; P = .52). Conclusions: This large prospective study provides evidence that shorter height may be a risk factor for incident IPH in women.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume22
Issue number4
DOIs
StatePublished - 2013

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts ( HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C ). CHS was funded by NHLBI contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133 , and NHLBI grant U01 HL080295 , with additional contribution from the National Institute of Neurological Disorders and Stroke. A full list of participating CHS investigators and institutions can be found at www.chs-nhlbi.org . The authors thank the staff and participants of the ARIC and CHS studies for their important contributions.

Keywords

  • Height
  • incident
  • intraparenchymal hemorrhage
  • stroke

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