TY - JOUR
T1 - Hedgehog signaling in gastric physiology and cancer
AU - Merchant, Juanita L.
AU - Saqui-Salces, Milena
AU - El-Zaatari, Mohamad
PY - 2010/11/29
Y1 - 2010/11/29
N2 - The Hedgehog family of ligands was originally identified in mutagenesis screens of Drosophila embryos. Hedgehog signaling in multiple tissues is important during embryonic development. A common theme regarding Hedgehog expression in adult tissues is that tissue injury reactivates the developmental pattern of expression. In most instances, this appears to be important to initiate tissue repair. In the gastrointestinal (GI) tract, where epithelial cells are constantly replenished from progenitor populations, Hedgehog signaling also appears to be essential for regeneration. By contrast, reactivated Hedgehog signaling in adult tissues does not automatically predispose the tissue to transformation, but instead requires sustained tissue injury in the form of chronic inflammation. In this chapter, we review what is known about Hedgehog ligands and signaling during development of relevant organs, and discuss how the patterns of Hedgehog regulation are recapitulated in the GI tract during embryogenesis, adult homeostasis, and neoplastic transformation.
AB - The Hedgehog family of ligands was originally identified in mutagenesis screens of Drosophila embryos. Hedgehog signaling in multiple tissues is important during embryonic development. A common theme regarding Hedgehog expression in adult tissues is that tissue injury reactivates the developmental pattern of expression. In most instances, this appears to be important to initiate tissue repair. In the gastrointestinal (GI) tract, where epithelial cells are constantly replenished from progenitor populations, Hedgehog signaling also appears to be essential for regeneration. By contrast, reactivated Hedgehog signaling in adult tissues does not automatically predispose the tissue to transformation, but instead requires sustained tissue injury in the form of chronic inflammation. In this chapter, we review what is known about Hedgehog ligands and signaling during development of relevant organs, and discuss how the patterns of Hedgehog regulation are recapitulated in the GI tract during embryogenesis, adult homeostasis, and neoplastic transformation.
KW - Cytokines
KW - Development
KW - Helicobacter
KW - Parietal cell
KW - Primary cilia
KW - Shh
UR - http://www.scopus.com/inward/record.url?scp=78649260066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649260066&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-381280-3.00006-3
DO - 10.1016/B978-0-12-381280-3.00006-3
M3 - Article
C2 - 21075343
AN - SCOPUS:78649260066
SN - 1877-1173
VL - 96
SP - 133
EP - 156
JO - Progress in Molecular Biology and Translational Science
JF - Progress in Molecular Biology and Translational Science
IS - C
ER -