Hedgehog signaling and gastrointestinal cancer

Milena Saqui-Salces, Juanita L. Merchant

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Hedgehog (Hh) signaling is critical for embryonic development and in differentiation, proliferation, and maintenance of multiple adult tissues. De-regulation of the Hh pathway is associated with birth defects and cancer. In the gastrointestinal tract, Hh ligands Sonic (Shh) and Indian (Ihh), as well as the receptor Patched (Ptch1), and transcription factors of Glioblastoma family (Gli) are all expressed during development. In the adult, Shh expression is restricted to the stomach and colon, while Ihh expression occurs throughout the luminal gastrointestinal tract, its expression being highest in the proximal duodenum. Several studies have demonstrated a requirement for Hh signaling during gastrointestinal tract development. However to date, the specific role of the Hh pathway in the adult stomach and intestine is not completely understood. The current review will place into context the implications of recent published data related to the biochemistry and cell biology of Hh signaling on the luminal gastrointestinal tract during development, normal physiology and subsequently carcinogenesis.

Original languageEnglish (US)
Pages (from-to)786-795
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1803
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Colon cancer
  • Gastric cancer
  • Gastric epithelium
  • Gastrointestinal development
  • Hedgehog signaling
  • Intestine

Fingerprint Dive into the research topics of 'Hedgehog signaling and gastrointestinal cancer'. Together they form a unique fingerprint.

  • Cite this