Heat-loss response to a thermal challenge in seasonal affective disorder

Paul A. Arbisi, Richard A. Depue, Steven Krauss, Michele R. Spoont, Arthur Leon, Barbara Ainsworth, Rachel Muir

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This study extends earlier findings of poorly facilitated postexercise heat loss during the winter in seasonal affective disorder (SAD). While depressed in the winter, 19 SAD subjects exhibited a significantly impaired postexercise heat loss relative to 10 control subjects. During the summer while euthymic, SAD subjects did not significantly differ from control subjects in postexercise heat loss. Since thermoregulatory heat loss is a highly dopamine-dependent process, these results support earlier findings of poorly facilitated dopamine availability in SAD during the winter and suggest a centrally mediated effect of light in SAD.

Original languageEnglish (US)
Pages (from-to)199-214
Number of pages16
JournalPsychiatry Research
Issue number2
StatePublished - May 1994

Bibliographical note

Funding Information:
Acknowledgments. The authorst hank Charlie Dean, M.D., and two anonymousr eviewers for helpful comments on earlier versions of this article. This work was supported by National Institute of Mental Health Research Grant MH-37195 to Dr. Depue.


  • Affective disorder
  • core body temperature
  • dopamine
  • thermoregulation


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