This study extends earlier findings of poorly facilitated postexercise heat loss during the winter in seasonal affective disorder (SAD). While depressed in the winter, 19 SAD subjects exhibited a significantly impaired postexercise heat loss relative to 10 control subjects. During the summer while euthymic, SAD subjects did not significantly differ from control subjects in postexercise heat loss. Since thermoregulatory heat loss is a highly dopamine-dependent process, these results support earlier findings of poorly facilitated dopamine availability in SAD during the winter and suggest a centrally mediated effect of light in SAD.
Bibliographical noteFunding Information:
Acknowledgments. The authorst hank Charlie Dean, M.D., and two anonymousr eviewers for helpful comments on earlier versions of this article. This work was supported by National Institute of Mental Health Research Grant MH-37195 to Dr. Depue.
- Affective disorder
- core body temperature