Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance

Aziz A. Khazaeli, Marc Tatar, Scott D. Pletcher, James W Curtsinger

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153 Scopus citations


Survival data were collected on a total of 28,000 Drosophila melanogaster adults in order to investigate mortality patterns and induced physiological responses after a mild thermal stress, A brief, nonlethal heat treatment extends adult life span at normal temperatures by an average of 2 days (64), compared to nontreated controls of the same genotypes. Life expectancy is extended as a demographic consequence of reduced age-specific mortality over a period of up to several weeks after the heat treatment. Heat treatment also increases tolerance to subsequent, more severe thermal stress. Observations on single-sex populations suggest that heat-induced longevity extension is independent of the suppression of reproductive activity.

Original languageEnglish (US)
Pages (from-to)B48-B52
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number1
StatePublished - 1997


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