Heart Transplantation in Adriamycin-Associated Cardiomyopathy in the Contemporary Era of Advanced Heart Failure Therapies

Bhavadharini Ramu, Maria Masotti, Ryan J. Tedford, Rebecca J. Cogswell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Adriamycin-associated cardiomyopathy (ACM) can lead to end-stage heart failure requiring advanced heart failure therapies. Objectives: This study sought to provide post–cardiac transplant survival data in patients with ACM in the contemporary era of mechanical circulatory support and cardiac transplantation. Methods: Adults (≥18 years of age) who underwent first-time, single-organ heart transplantation were identified from the United Network for Organ Sharing between October 18, 2008, and October 18, 2018. Cardiomyopathy subtypes that could have been supported with a left ventricular assist device (LVAD) including ACM, dilated cardiomyopathy (DCM), and ischemic cardiomyopathy (ICM) were included. A multivariable Cox regression analysis was performed to determine the association between cardiomyopathy subtype and post–cardiac transplant survival. Results: This analysis included 18,270 patients (357 with ACM; 10,662 with DCM; and 7,251 with ICM). Heart transplant recipients with ACM were younger, included more women, and had higher pulmonary vascular resistance at the time of listing. Patients with ACM had a lower percentage of durable LVADs at the time of transplant across all years of the study period. Patients with ACM did not experience an increase in post–cardiac transplant mortality compared to those with DCM (adjusted hazard ratio: 0.96; 95% confidence interval: 0.79 to 1.40; p = 0.764) or ICM (adjusted hazard ratio: 0.85; 95% confidence interval: 0.6 to 1.2; p = 0.304). Conclusions: Patients with ACM who received heart transplants between 2008 and 2018 had similar post–cardiac transplant survival to those with dilated and ischemic cardiomyopathy. Bridge-to-transplant LVAD use remains lower compared to other cardiomyopathy subtypes.

Original languageEnglish (US)
Pages (from-to)294-301
Number of pages8
JournalJACC: CardioOncology
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2021

Bibliographical note

Funding Information:
The authors thank the administrators at UNOS for their assistance in preparing the Standard Transplant Analysis and Research files.

Publisher Copyright:
© 2021 The Authors

Keywords

  • adriamycin cardiomyopathy
  • cardiac transplantation
  • left ventricular assist device

PubMed: MeSH publication types

  • Journal Article

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