Heart transplantation for radiation-associated end-stage heart failure

Nobuhiro Handa, Christopher G.A. McGregor, Richard C. Daly, Joseph A. Dearani, Brooks S. Edwards, Robert P. Frantz, Lyle J. Olson, Richard J. Rodeheffer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalTransplant International
Issue number2
StatePublished - Mar 2000
Externally publishedYes

Bibliographical note

Copyright 2017 Elsevier B.V., All rights reserved.


  • Heart transplantation
  • Radiation-induced heart disease


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