TY - JOUR
T1 - Heart rate variability analysis is more sensitive at identifying neonatal sepsis than conventional vital signs
AU - Bohanon, Fredrick J.
AU - Mrazek, Amy A.
AU - Shabana, Mohamed T.
AU - Mims, Sarah
AU - Radhakrishnan, Geetha L.
AU - Kramer, George C.
AU - Radhakrishnan, Ravi S.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. Methods With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain. Results HRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls. Conclusions These results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
AB - Background Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. Methods With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain. Results HRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls. Conclusions These results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
KW - Heart rate variability
KW - Neonatal
KW - Noninvasive vital signs
KW - Sepsis
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U2 - 10.1016/j.amjsurg.2015.06.002
DO - 10.1016/j.amjsurg.2015.06.002
M3 - Article
C2 - 26212391
AN - SCOPUS:84941943547
SN - 0002-9610
VL - 210
SP - 661
EP - 667
JO - American journal of surgery
JF - American journal of surgery
IS - 4
ER -