Heart rate and age modulate retinal pulsatile patterns

Ivana Labounková; Rene Labounek; Radim Kolář; Ralf P. Tornow; Charles F. Babbs; Collin M. McClelland; Benjamin R. Miller; Igor Nestrašil

doi:10.1038/s42003-022-03441-6

Heart rate and age modulate retinal pulsatile patterns

Ivana Labounková, Rene Labounek, Radim Kolář, Ralf P. Tornow, Charles F. Babbs, Collin M. McClelland, Benjamin R. Miller, Igor Nestrašil

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3 Scopus citations

Abstract

Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p_FDR < 0.05); age modulated SVP morphology (p_FDR < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Original language	English (US)
Article number	582
Journal	Communications biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/s42003-022-03441-6
State	Published - Dec 2022

Bibliographical note

Funding Information:
The authors thank Dr. Folkert Horn and other staff of the Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg at Erlangen for their clinical support and information provided to our research team during this study. Also, the authors thank the Center for Behavioral Development and the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota for providing the lab space and computational support. The study was supported by several grand awards: Brno University of Technology grant n. FEKT-S-17-4487, Czech Science Foundation, project no. 21-18578 S, Deutsche Forschungsgemeinschaft (DFG) grant number DFG TO 115/3-1, and “Progressive” grant, stage 3 from the Department of Pediatrics and the Winston & Maxine Wallin Neuroscience Discovery Fund, University of Minnesota. All funding is highly acknowledged.

Funding Information:
The authors thank Dr. Folkert Horn and other staff of the Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg at Erlangen for their clinical support and information provided to our research team during this study. Also, the authors thank the Center for Behavioral Development and the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota for providing the lab space and computational support. The study was supported by several grand awards: Brno University of Technology grant n. FEKT-S-17-4487, Czech Science Foundation, project no. 21-18578 S, Deutsche Forschungsgemeinschaft (DFG) grant number DFG TO 115/3-1, and “Progressive” grant, stage 3 from the Department of Pediatrics and the Winston & Maxine Wallin Neuroscience Discovery Fund, University of Minnesota. All funding is highly acknowledged.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Heart Rate
Humans
Intraocular Pressure
Optic Disk
Pulsatile Flow/physiology
Retinal Vein/physiology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1038/s42003-022-03441-6

https://www.nature.com/articles/s42003-022-03441-6.pdfLicense: CC BY

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title = "Heart rate and age modulate retinal pulsatile patterns",

abstract = "Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (pFDR < 0.05); age modulated SVP morphology (pFDR < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.",

keywords = "Heart Rate, Humans, Intraocular Pressure, Optic Disk, Pulsatile Flow/physiology, Retinal Vein/physiology",

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note = "Funding Information: The authors thank Dr. Folkert Horn and other staff of the Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-N{\"u}rnberg at Erlangen for their clinical support and information provided to our research team during this study. Also, the authors thank the Center for Behavioral Development and the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota for providing the lab space and computational support. The study was supported by several grand awards: Brno University of Technology grant n. FEKT-S-17-4487, Czech Science Foundation, project no. 21-18578 S, Deutsche Forschungsgemeinschaft (DFG) grant number DFG TO 115/3-1, and “Progressive” grant, stage 3 from the Department of Pediatrics and the Winston & Maxine Wallin Neuroscience Discovery Fund, University of Minnesota. All funding is highly acknowledged. Funding Information: The authors thank Dr. Folkert Horn and other staff of the Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-N{\"u}rnberg at Erlangen for their clinical support and information provided to our research team during this study. Also, the authors thank the Center for Behavioral Development and the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota for providing the lab space and computational support. The study was supported by several grand awards: Brno University of Technology grant n. FEKT-S-17-4487, Czech Science Foundation, project no. 21-18578 S, Deutsche Forschungsgemeinschaft (DFG) grant number DFG TO 115/3-1, and “Progressive” grant, stage 3 from the Department of Pediatrics and the Winston & Maxine Wallin Neuroscience Discovery Fund, University of Minnesota. All funding is highly acknowledged. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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AU - Babbs, Charles F.

AU - McClelland, Collin M.

AU - Miller, Benjamin R.

AU - Nestrašil, Igor

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Heart rate and age modulate retinal pulsatile patterns

Abstract

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Keywords

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