Heart failure, oxidative stress, and ion channel modulation

Gaurav Choudhary, Samuel C. Dudley

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The balance of reactive oxygen species (ROS) and nitric oxide, the cell redox state, appears to be important in the mechanisms of heart failure. This balance has significant impact on calcium-handling proteins, affecting excitation-contraction coupling. Both ROS and nitric oxide appear to be elevated in heart failure and are accompanied by significant impairments in the number and function of calcium-handling proteins. These proteins contain sulfhydryl groups or disulfide linkages involving cysteine residues, making them susceptible to the action of oxidizing-reducing agents and nitrosylation, thereby altering their properties. Initial increases in nitric oxide may be an adaptive response to myocardial dysfunction, elevated cytokines, and increases in ROS, while a further increase in nitric oxide and overwhelming ROS can be damaging. Abundant nitric oxide and ROS can cause formation of peroxynitrite, a strong oxidant, or nitric oxide can activate alternate pathways aiding the ROS, causing impaired calcium handling contributing to contractile dysfunction.

Original languageEnglish (US)
Pages (from-to)148-155
Number of pages8
JournalCongestive Heart Failure
Volume8
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

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