Heart Failure

S. M. Hamza, N. Sharma, M. M. Sung, B. N. Zordoky, P. F. Kantor, J. R.B. Dyck

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cardiovascular disease is the leading cause of death and disabiLity in the world. By 2015, the World Health Organization predicts that cardiovascular disease will become the leading cause of death worldwide. While advancements in medical and surgical therapies have improved cardiac mortaLity, these advances have led to an increase in the incidence and prevalence of heart failure (HF). Indeed, 75% of cardiovascular patients with ischemic and hypertensive-heart disease will eventually develop HF, emphasizing the impact of this global epidemic. Symptomatic HF affects milLions of people worldwide and incurs bilLions of dollars in hospital costs annually, and the burden is expected to double in the next 1-2 decades. In addition, the current 1-year mortaLity rate after diagnosis of HF remains disturbingly high at 25-40%, and the condition has the worst effect on quaLity of Life of any chronic medical condition. This chapter will review the primary causes of adult HF and highLight causes of HF in the pediatric population.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Number of pages24
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
StatePublished - Jan 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.


  • Animal models
  • Biomarkers
  • Diabetic cardiomyopathy
  • Heart failure
  • Hypertensive-heart disease
  • Hypertrophic cardiomyopathy
  • Infiltrative cardiomyopathies
  • Ischemic cardiomyopathy


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